Somebody else figured it out in 2009, and I’m late to the party.

Basically, if you are running Red Hat Enterprise Linux (or one of it’s clone siblings) on a Dell M600 blade, you’ll need to modify the default BIOS settings in a non-intuitive way or you’ll get an error on every boot-up.

IRQ handler type mismatch for IRQ 12

Call Trace:
[] setup_irq+0x1b7/0x1cf
[] serial8250_interrupt+0x0/0xfe
[] request_irq+0xb0/0xd6
[] serial8250_startup+0x43d/0x5dc
[] uart_startup+0x76/0x16c
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[] tty_open+0x1e8/0x3b0
[] chrdev_open+0x14d/0x183
[] open_namei+0x2be/0x6ba
[] chrdev_open+0x0/0x183
[] __dentry_open+0xd9/0x1dc
[] do_filp_open+0x2a/0x38
[] do_sys_open+0x44/0xbe
[] tracesys+0xd5/0xdf

I knew this was a serial port issue from the second and fifth lines of the trace, but I couldn’t figure out why it was involving IRQ 12, which is normally used for SCSI cards or PS/2 mice.